Description

Basic information

Product Name：Palmitoyl tripeptide-5; Pal-AHK
INCI Name：Palmitoyl Tripeptide-5
CAS NO.：623172-56-5
MF： C35H66F3N5O7
MW： 725.94
Appearance：White to off white powder
Purity：≥98.0%
Function: Anti-wrinkle and Antiaging

Application

Palmitoyl Tripeptide-5 is a synthetic signal peptide designed to penetrate deep into the skin's dermal layers to stimulate collagen production and tissue repair. Known globally as a premium anti-aging active, it effectively mimics the body's own mechanism to produce collagen via Tissue Growth Factor-beta (TGF-β).

Mechanism of Action: Advanced TGF-β Mimetic Cascade

The primary limitation of traditional anti-aging ingredients is their inability to efficiently activate the skin's endogenous repair pathways. Palmitoyl Tripeptide-5 overcomes this by acting as a highly specific TGF-β (Transforming Growth Factor-beta) mimetic.

The Cellular Signaling Pathway:

Thrombospondin-1 (TSP-1) Mimicry: Palmitoyl Tripeptide-5 mimics a specific sequence of TSP-1, a key molecule responsible for activating latent (inactive) TGF-β.
Receptor Binding & Activation: It binds directly to the inactive TGF-β complex, triggering a conformational change that releases active, bio-available TGF-β.
Smad Pathway Phosphorylation: Active TGF-β binds to cell-surface receptors (TGF-βRII/I), initiating the phosphorylation of intracellular Smad2 and Smad3 proteins.
Collagen Gene Expression: The Smad complex translocates into the nucleus, binding to specific promoter regions to upregulate the transcription of Collagen Type I, Type III, and Fibronectin.

Collagen Synthesis Booster: Competitive Benchmarking

In-vitro cell culture assays demonstrate that JoyBiotech's Palmitoyl Tripeptide-5 outperforms traditional anti-aging standards (such as Matrixyl and standard Vitamin C) in promoting collagen synthesis within human dermal fibroblasts.

Active Ingredient Tested	Concentration (μg/mL)	Collagen Type I Synthesis Rate (%)	Fibronectin Synthesis Rate (%)
JoyBiotech Palmitoyl Tripeptide-5	10 μg/mL	+119% Increase	+67% Increase
Market Baseline (Standard Matrixyl)	10 μg/mL	+85% Increase	+42% Increase
L-Ascorbic Acid (Vitamin C)	50 μg/mL	+54% Increase	+28% Increase
Control Group (Untreated Fibroblasts)	0 μg/mL	0% (Baseline)	0% (Baseline)

Formulation recommendations

Recommended dosage of Palmitoyl tripeptide 5 in cosmetics

10-100ppm

Compatibility suggestion for Palmitoyl tripeptide 5

Palmitoyl tripeptide 5 is slightly soluble in water, and can be solubilized by using solubilizers. Avoid being mixed with strong acids, strong alkalis, strong oxidants, acyl chlorides and acid anhydrides. Palmitoyl Tripeptide-5 has relatively high biological activity.

Precautions of Palmitoyl tripeptide 5

It is recommended that the operating temperature during the preparation process be kept lower than 45℃, and it be added at the final stage of the formulation system.

Packaging and delivery

Packaging of Palmitoyl tripeptide-5

Double layers of LDPE bags, one layer of Foil bag, packed in a carton or drum according to the quantity.

Packing specification can be customized from gram to kg

100~500g/bag or bottle, 1kg/carton, 10kg/carton, 25kg/drum

Storage

Short-term storage: Room temperature for a short period.

Optimal storage: Refrigerator temperature (4°C)

Long-term storage: Freezer temperature (-20°C to -80°C)

Important consideration: Avoid repeated freeze-thaw cycles.

Company Profile

Shanghai Joy Biotech Ltd. is a professional supplier of Cosmetic ingredients like Palmitoyl tripeptide-5, , Dietary supplements, pharmaceutical raw materials, etc. We have team members of post-doctors, doctors, masters, Bachelors in the field of pharmaceuticals,chemistry, Biology.

Joy Biotech provides professional service in both sourcing chemical products, and CMO, CDMO,custom synthesis .