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Your Professional Tirzepatide Intermediates Supplier

 

Our goal is to become your true partner in the field of tirzepatide intermediates in China. Joy BIotech is a professional supplier and manufacturer of cosmetic ingredients,pharmaceutical raw materials, Intermediates, APIs, Dietary supplements, ,etc. Our service covers export & Import, custom synthesis, CMO/CDMO of chemical and synthesis biology products. The factory has accumulated rich manufacturing experience. Our company is committed to applying advanced manufacturing technology and strict quality control standards to every product. The price is competitive and the product is quality-assured, which is a good choice for your long-term cooperation.

 

 

 

 

 

Why Choose Us
 

Quality Control
QC team members are all qualified and receive regular training. A professional QA team ensures quality products and a sound documentation system is in place to support audits.

 

Our Team
Joy Biotech team members include postdocs, doctors, masters, bachelors in the fields of synthetic biopharmaceuticals, chemistry, biology.

 

Our Services
We not only provide quality products, but also the best pre-sales and after-sales services. Our goal is to build a long-term relationship with every customer. If you have questions or problems, please feel free to contact us by email, phone, WhatsApp... We will respond to you as soon as possible within 24 hours.

 

Fast Delivery
For products in stock, we can deliver immediately after receiving your payment. For synthetic chemicals, we will provide delivery time when quoting.

 

Benefits of Tirzepatide Intermediates

 

Tirzepatide

Improves Metabolic Health

In addition to weight loss, tirzepatide improves metabolic markers like blood glucose levels and insulin sensitivity. This makes it an ideal choice for people who are battling both obesity and type 2 diabetes or prediabetes, helping them tackle both conditions simultaneously.

Tirzepatide

Non-Surgical Weight Loss Solution

Unlike bariatric surgery, tirzepatide offers a non-invasive alternative that doesn’t require months of recovery or lifestyle limitations. Many people searching for "how to lose weight without surgery" or "best weight loss injections" are turning to this treatment due to its convenience and minimal side effects.

Tirzepatide

Reduces Appetite and Cravings

One of the biggest challenges when trying to lose weight is dealing with hunger and cravings. Tirzepatide works by regulating hormones that control hunger, making it easier to maintain a calorie deficit. Those who use tirzepatide often report feeling fuller for longer, which translates into less snacking and fewer cravings for unhealthy foods.

 

Application of Tirzepatide Intermediates

 

 

Tirzepatide injection is used to treat type 2 diabetes. It is used together with diet and exercise to help control your blood sugar. Tirzapatide is a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist.

 

Specification of Tirzepatide Intermediates

 

 

Product Name

Tirzepatide Intermediates

Appearance

White to off-white powder

Solubility

Soluble in DMSO

Remarks

Not directly for patients

 

Production Process of Tirzepatide Intermediates

 
 

In the preparation method of the tirzepatide, the dosage of the protected amino acid or the protected amino acid fragment is 1.2-6 times of the total mole number of the charged resin; preferably 2.5 to 3.5 times. The tirzepatide resin is subjected to acidolysis while removing the resin and the side chain protecting groups to obtain a crude tirzepatide linear peptide.

 
 

Further, an acidolysis agent adopted in the acid hydrolysis of the tirzepatide resin is a mixed solvent of trifluoroacetic acid (tfa), 1, 2-ethanedithiol (edt) and water, and the mixture ratio of the mixed solvent is as follows: The tfa ratio is 80-95% (v/v), the edt ratio is 1-10% (v/v), and the balance is water. The preferred formulation is 89-91% tfa, 4-6% edt, and the balance water. Preferably, the mixture ratio is 90%, edt 5% and the balance of water.

 
 

The dosage of the acidolysis agent is 4-15 ml of acidolysis agent per gram of tirzepatide resin, and preferably 9-11 ml of acidolysis agent per gram of tirzepatide resin. The time for cracking by using the acidolysis agent is 1-5 hours, preferably 2 hours at room temperature.

 
 

Purifying by high performance liquid chromatography, wherein a chromatographic filler for purification is 10 mu m reverse phase c18, alternately purifying by two mobile phase systems, the first mobile phase system is 0.1% tfa/aqueous solution-0.1% tfa/acetonitrile solution, the second mobile phase system is 50mmol ammonium acetate/aqueous solution-acetonitrile, the flow rate of a 77mm 250mm chromatographic column is 90ml/min, eluting by a gradient system, circularly injecting and purifying, sampling a crude product solution in the chromatographic column, starting mobile phase elution, collecting a main peak, evaporating acetonitrile, and filtering by a 0.45 mu m filter membrane to obtain a tirzepatide intermediates concentrated solution.

 

 

Dose of Tirzepatide Intermediates
 
 

Initial dose

2.5 mg under the skin (subcutaneously) once a week. After 4 weeks: The dosage should be increased to 5 mg subcutaneously once a week. Further dose increases: After at least 4 weeks on the current dose the dosage may be increased in 2.5 mg increments.

 
 
 

Recommended maintenance dose for weight loss

5 mg, 10 mg, or 15 mg injected subcutaneously once weekly. Recommended maintenance dose for OSA: 10 mg or 15 mg injected subcutaneously once weekly. Maximum dose: 15 mg subcutaneously once a week.

 
 
 

nitial dose

I2.5 mg under the skin (subcutaneously) once a week. After 4 weeks: The dosage should be increased to 5 mg subcutaneously once a week. If additional glycemic control is needed: The dosage should be increased in 2.5 mg increments after at least 4 weeks on the current dose. Maximum dose: 15 mg subcutaneously once a week.

 

 

Tirzepatide

 

Storage of Tirzepatide Intermediates

Store in the refrigerator between 36⁰F to 46⁰F (2⁰C to 8⁰C). Do not freeze. Do not use if frozen. Store the single-dose pens in the original carton until use to protect them from light. If needed, each single-dose pen can be stored at room temperature up to 86⁰F (30⁰C) for up to 21 days.

 

Packing and Delivery of Tirzepatide Intermediates

 

 

Packing

25kg/drum; 5kg/carton. Or customize packing size from gram to kg.

Delivery

By air, by sea, by express. Sample and products in small quantity can be delivered by DHL, Fedex,TNT,UPS.

 

FAQ

 

Q: Can I get tirzepatide for weight loss?

A: Tirzepatide is a once-weekly injection given under the skin using a pen (autoinjector). Zepbound (tirzepatide) is FDA-approved for weight loss in adults with obesity or who are overweight and have weight-related medical problems or OSA.

Q: How much weight can you lose on tirzepatide in 3 months?

A: As you can see, the average weight loss is 7.59 pounds in the first month, 12.86 pounds over the first two months, 18.23 pounds over the first three months, 23.49 pounds over the first four months, 27.27 pounds over the first five months, 32.83 pounds over the first six months.

Q: Will I gain weight after stopping tirzepatide?

A: Stopping Tirzepatide often leads to weight gain if not accompanied by sustainable lifestyle modifications. While Tirzepatide can foster significant weight loss, its discontinuation requires strategic planning to maintain a healthy weight.

Q: What not to do on tirzepatide?

A: It's best to avoid overly processed or fried foods while taking Tirzepatide. Fried foods contain saturated and trans fats, which disrupt digestion and can decrease the medication's effectiveness. This includes sodas or any beverage high in sugar.

Q: How long do you stay on tirzepatide?

A: The duration of Tirzepatide treatment for weight loss should be individualized based on the patient's response and tolerability. Clinical studies have generally observed patients over periods stretching up to 72 weeks, with ongoing assessment for efficacy and safety.

Q: Does tirzepatide make you sleepy?

A: Although fatigue is not commonly listed, some users of Tirzepatide report feeling unusually tired. You might feel a persistent sense of tiredness or lack of energy, which can affect daily activities. However, you can make certain lifestyle changes to feel more energetic.

Q: Does tirzepatide make you lose hair?

A: Hair loss is a side effect that has been associated with significant weight loss in many previous clinical trials for obesity treatment.

Q: Can you drink wine while taking tirzepatide?

A: Unless otherwise advised by your medical provider, most people can drink alcohol in moderation while taking. Keep in mind that some of the side effects of Mounjaro may be worsened with alcohol intake.

Q: Does tirzepatide affect the liver?

A: In patients with type 2 diabetes mellitus, treatment with tirzepatide resulted in a reduction in liver fat and improvement in biomarkers of MASH and fibrosis.

Q: Does tirzepatide burn visceral fat?

A: Tirzepatide (TZP), a novel, once-weekly GIP/GLP-1 receptor agonist, significantly reduced liver fat content (LFC) and volumes of visceral and abdominal subcutaneous adipose tissue (VAT and ASAT) vs insulin degludec in a subpopulation of patients in the SURPASS-3 phase 3 trial.

We're well-known as one of the leading tirzepatide intermediates manufacturers and suppliers in China. If you're going to buy high quality tirzepatide intermediates, welcome to get quotation from our factory. For price consultation, contact us.

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