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Your Professional Netupitant Intermediates Supplier

 

Our goal is to be your true partner in the netupitant intermediates in China.Joy biotech is a professional supplier and manufacturer of cosmetic ingredients,pharmaceutical raw materials, intermediates, apis, dietary supplements, ,etc. Our service covers export & import, custom synthesis, cmo/cdmo of chemical and synthesis biology products. The factory has accumulated rich manufacturing experience. Our company is committed to applying advanced manufacturing technology and strict quality control standards to every product. The price is competitive and the product is quality-assured, which is a good choice for your long-term cooperation.

 

 
 
Why Choose Us
 

Quality Control
QC team members are all qualified and receive regular training. A professional QA team ensures quality products and a sound documentation system is in place to support audits.

 

Our Team
Joy Biotech team members include postdocs, doctors, masters, bachelors in the fields of synthetic biopharmaceuticals, chemistry, biology.

 

Our Services
We not only provide quality products, but also the best pre-sales and after-sales services. Our goal is to build a long-term relationship with every customer. If you have questions or problems, please feel free to contact us by email, phone, WhatsApp... We will respond to you as soon as possible within 24 hours.

 

Fast Delivery
For products in stock, we can deliver immediately after receiving your payment. For synthetic chemicals, we will provide delivery time when quoting.

 

Advantages of Netupitant Intermediates

Netupitant is a selective neurokinin-1 receptor antagonist with antiemetic properties; it is recently approved by the fda in 2018 to be used with palonosetron for the prevention of acute and delayed vomiting caused by chemotherapy, at a dose of netupitant 300 mg and palonosetron 0.5 mg orally. The drug has a peak plasma concentration at approximately 5 h.

 

Specification of Netupitant Intermediates

 

 

Product Name

Nedaplatin

CAS number

95734-82-0

Molecular formula

C2H6N2O3Pt

Molecular weight

301.17

Appearance

White powder

Assay

99%+

 

Application of Netupitant Intermediates

 

 

Netupitant intermediates application of it is applied to head and neck cancer, lung cancer, testicular cancer, esophageal cancer and cervical cancer.

 

 

Precautions of Netupitant Intermediates

Hypersensitivity reactions (eg, anaphylaxis) reported in patients treated with palonosetron, with or without known hypersensitivity to other 5-ht3 receptor antagonists

 

Serotonin syndrome has been reported with 5-ht3 receptor antagonists (eg, palonosetron); most reports have been associated with concomitant use of serotonergic drugs (eg, selective serotonin reuptake inhibitors (ssris), serotonin and norepinephrine reuptake inhibitors (snris), monoamine oxidase inhibitors, mirtazapine, fentanyl, lithium, tramadol, and iv methylene blue); discontinue netupitant-palonosetron if symptoms occur

 

Drug interactions overview

  • Netupitant is a cyp3a4 substrate and a moderate inhibitor of cyp3a4
  • Palonosetron is mainly metabolized by cyp2d6 and to a lesser extent by cyp3a4 and cyp1a2
  • Strong cyp3a4 inducers (e.G., rifampin) can decrease netupitant-palonosetron efficacy by substantially reducing plasma concentrations of the netupitant component; avoid use
  • Concomitant use with a strong cyp3a4 inhibitor (e.G., ketoconazole) can increase the systemic exposure to the netupitant component; no dosage adjustment is necessary for single dose administration
N-tert-butyl-6-chloro-4-(o-tolyl)nicotinamide

 

Packing and Delivery of Netupitant Intermediates

 

 

Packing

Double layers of pe bags, and one layer of an aluminum foil bag inside, and packed in a drum.50g/bottle, 25kg/drum, or customize from gram to kg.

Delivery

By air; By sea; By express such as DHL,Fedex,TNT etc.

 

FAQ

 

Q: What class drug is netupitant?

A: Netupitant is in a class of medications called neurokinin (nk1) antagonists. It works by blocking neurokinin, a natural substance in the brain that causes nausea and vomiting.

Q: What are the pharmacokinetics of netupitant?

A: Netupitant and palonosetron have high absolute bioavailability (63%‐87% and 97%, respectively). Their overall systemic exposures and maximum plasma concentrations are similar under fed and fasting conditions. Netupitant binds to plasma proteins in a high degree (>99%), whereas palonosetron binds to a low extent (62%).

Q: What class of bcs is netupitant?

A: Netupitant is a new bcs class ii compound developed in a tablet form and combined with the existing compound palonosetron formulated in a soft capsule filled into a single hard capsule.

Q: What is the difference between netupitant and fosnetupitant?

A: Fosnetupitant is a 'prodrug' of netupitant, meaning that it is converted into the active substance netupitant in the body. By having palonsetron and netupitant or fosnetupitant together, akynzeo helps provide control for both the immediate and delayed phases of nausea and vomiting than occur following chemotherapy.

Q: What is the composition of netupitant?

A: Netupitant is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoic acid with the secondary amino group of n-methyl-4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-amine; an antiemetic used in combination with palonosetron ...

 

We're well-known as one of the leading netupitant intermediates manufacturers and suppliers in China. If you're going to buy high quality netupitant intermediates, welcome to get quotation from our factory. For price consultation, contact us.

Hydrolyzed Conchiolin Protein HCP , COPPER TRIPEPTIDE 1, N-Acetyl-5-methoxytryptamine
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