Basic information
3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate (CAS: 179268-65-4) is a critical core building block utilized in the commercial synthesis route of Gefitinib (Iressa), an EGFR tyrosine kinase inhibitor widely indicated for non-small cell lung cancer (NSCLC).
At Joy Biotech, we provide commercial-scale supply with batch-to-batch consistency and an analytical purity of ≥ 99.0% (HPLC). Manufactured under strict ISO/cGMP-aligned quality management systems, our intermediate guarantees reliable conversion yields and minimal residual impurity profiles during subsequent quinazoline ring functionalization steps.
B2B Advantage & Regulatory Support:
Fully supported with comprehensive technical dossier packages including CoA, HPLC, Mass Spec (MS), 1H-NMR spectra, stability data, and Drug Master File (DMF) documentation to accelerate your regulatory submission and commercial API manufacturing.
Gefitinib Synthesis Pathway & Intermediate Hierarchy
| Synthesis Stage | Intermediate Chemical Name | CAS Number | Chemical Function / Role |
| Stage 1 (Current Product) | 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate | 179268-65-4 | Core Quinazoline Ring Scaffold |
| Stage 2 Intermediate | 4-Chloro-7-methoxyquinazolin-6-yl acetate | 184475-35-2 | Direct Activation / Chlorination Step |
| Stage 3 Intermediate | N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine | 199796-12-8 | Advanced Precursor to Gefitinib API |
Specification
| Product Name | 3,4-dihydro-7-methoxy-4-oxoquinazolin-6-yl Acetate |
| CAS NO | 179688-53-0 |
| Test items | Standards |
| Appearance | Off-white to pale brown powder |
| Identification | The retention time of the major peak of the sample solution correspond to that of the standard solution |
| Loss on Drying | ≤1.0% |
| Residue on Ignition | ≤0.5% |
| Related Substance | Individual impurities ≤0.5% |
| Total impurities ≤1.0% | |
| Purity | ≥99.0% |
Solvent Compatibility & Processing Behavior
To optimize downstream reaction yield and recrystallization parameters, review our solvent solubility guidelines for CAS 179268-65-4:
DMSO / DMF (Aprotic Polar): Freely Soluble (> 50 mg/mL at 25°C). Ideal for homogeneous reaction systems and analytical sample preparation.
DCM / Chloroform (Chlorinated): Moderately Soluble (Slightly warm). Suitable for organic phase extraction and liquid-liquid separation.
Methanol / Ethanol (Protic Polar): Slightly Soluble at RT, Soluble upon heating. Recommended for crystallization and purification steps.
Water: Practically Insoluble (< 0.1 mg/mL). Used as an anti-solvent for precipitate recovery and aqueous washing protocols.
Production
Production:
Adopted the latest equipment and technology to ensure the quality of the product reaches the international level
Focus on scientific research and innovation and technological upgrading, and constantly launch new products to meet market demand
Because of our advanced production technology and equipment, the chemical plant is able to produce chemical products more efficiently.
Delivery
After order and payment, we will arrange the shipment asap.
You can choose the Shipment term , by air, by sea, or by express.
Company Profile
Joy Biotech is a expert supplier of pharmaceutical raw materials 3,4-dihydro-7-methoxy-4-oxoquinazolin-6-yl Acetate, APIs, Intermediates, pharmaceutical building blocks, Dietary supplements, Nutrition supplements, Cosmetic ingredients etc. We moreover do custom synthesis business, CMO and CDMO.
Custom synthesis/CDMO/CMO Service
Our professional R&D dept. can develop the compounds according to your requirements. Or manufacture the products according to your technology package.
R&D LabR&D team is led by post-doctor with abroad education experience,and team members consist of 5 doctors, 18 Masters, and 25 bachelors, who are expert in choosing and design the synthesis route of chemicals.
End-to-End Quality Assurance
Quality control protocols are rigorously implemented across:
• Raw Material Screening
• In-Process Controls
• Final Product Certification
Our Certificates
Our certificates are complete and trustworthy
