Liraglutide

 

Fmoc-Thr(tBu)-Ser(psi(Me,Me)pro)-OH is a crucial pseudo-proline dipeptide intermediate specifically optimized for the solid-phase synthesis of GLP-1 receptor agonists, particularly Liraglutide and related therapeutic peptides. By disrupting secondary structure formation (beta-sheet aggregation) during chain elongation, this high-grade intermediate significantly increases coupling efficiency, raw material yield, and overall crude peptide purity.

 

Engineered for seamless integration into pilot-plant and industrial-scale peptide synthesizers, our product is batch- tested for strict physical-chemical consistency, ultra-low moisture levels, and predictable solubility kinetics across standard peptide chemistry solvents.

 

High Purity   HPLC Purity ≥ 98.5% with individual impurities rigorously controlled below 0.5% for consistent synthesis yields.
Commercial Scale   Multi-kilogram to commercial ton batch capability supported by automated reaction units and robust process validation.
Peptide-Grade Solvents   Optimized for immediate dissolution in DMF, DCM, and NMP without residual particulates or slow solvation delays.

Complete Regulatory Dossier   Full CoA, HPLC/MS/NMR spectra, TGA, and stability data readily available for regulatory filings.

 

 

 

 

Liraglutide is an anti-diabetic medicinal drug used to deal with type II diabetes, and persistent obesity.

 

Liraglutide injection is used to decrease blood sugar in adults with type II diabetes with a reduced-calorie food regimen and workout at the equal time.

 

Liraglutide medicinal drug is solely accessible with your doctor's prescription.

 

       

      Specification

 

 

TECHNICAL	PARAMETER SPECIFICATION / ACCEPTANCE CRITERIA	TESTING METHOD / STANDARD
Appearance	White to off-white powder	Visual Inspection
Chemical Purity (HPLC)	≥ 98.5% (Single max impurity ≤ 0.50%)	In-house HPLC-UV Method
Enantiomeric Purity (Chiral)	D-enantiomer≤ 0.3%	Chiral HPLC
Karl Fischer Moisture Content (KF)	≤ 0.50% w/w (Critical for coupling yield)	Karl Fischer Coulometric Titration
Particle Size Distribution (PSD)	D10 ≥ 5 μm D50: 25 μm – 50 μm D90 ≤ 120 μm (Micronized on demand)	Laser Diffraction (Dry Powder)
Residual Solvents	Meets ICH Q3C Limits (DMF, DCM, MeOH)	Headspace GC-MS
Heavy Metals / Residue on Ignition	≤ 20 ppm / ROI ≤ 0.1%	USP <231> / Thermogravimetry

 

 

      Solubility Profile (25°C Standard Conditions)

 

 

SOLVENT SYSTEM	SOLUBILITY LIMIT (G/100 ML)	SOLUTION CLARITY & BEHAVIOR
N,N-Dimethylformamide (DMF)	> 35 g / 100 mL	Clear, colorless, zero turbidity / suspended solids
Dichloromethane (DCM)	> 28 g / 100 mL	Clear solution within 3 minutes under mild agitation
N-Methyl-2-pyrrolidone (NMP)	> 30 g / 100 mL	Fully soluble, optimal for automated SPPS systems
Water	Insoluble (< 0.01 g / 100 mL)	Hydrophobic peptide intermediate

 

 

Whether you are performing initial solid-phase optimization or operating commercial-scale production lines for Liraglutide APIs, our production facility guarantees seamless scalability, rapid fulfillment, and strict batch-to-batch reproducibility.

 

Commercial Supply Scale: Multi-kilogram in-stock inventory available for 48-hour global dispatch; annual supply capacity exceeds 5 Metric Tons.
Related Industrial Reagent Portfolio: In addition to specialized GLP-1 pseudo-proline dipeptides, we manufacture premium oxidation and coupling reagents, including Bulk 2-Iodobenzoic Acid for Industrial Synthesis and hypervalent iodine derivatives at commercial scale.
Packaging & Stability: Standard commercial packing in 1kg, 5kg, and 25kg double PE-lined fiber drums under inert argon gas atmosphere to maintain low moisture (KF) during global transit.

 

 

As a professional supplier of building blocks such as Liraglutide (CAS No is 204656-20-2), pharmaceutical raw materials, Intermediates, APIs, Dietary supplements, Cosmetic ingredients etc.

Shanghai Joy Biotech Ltd aims to share Joy of beautiful and healthy life!