![6-Bromo-4-(6-fluoro-3-pyridinyl)-pyrazolo[1,5-a]pyridine-3-carbonitrile CAS NO 2222756-24-1](/uploads/43157/6-bromo-4-6-fluoro-3-pyridinyl-pyrazolo-1-5-a78256.png)
![6-Bromo-4-(6-fluoro-3-pyridinyl)-pyrazolo[1,5-a]pyridine-3-carbonitrile CAS NO 2222756-24-1](/uploads/202543157/6-bromo-4-6-fluoro-3-pyridinyl-pyrazolo-1-5-a73287709-e681-4fae-b4d6-c738e01ae967.png "6-Bromo-4-(6-fluoro-3-pyridinyl)-pyrazolo[1,5-a]pyridine-3-carbonitrile CAS NO 2222756-24-1")
![6-Bromo-4-(6-fluoro-3-pyridinyl)-pyrazolo[1,5-a]pyridine-3-carbonitrile CAS NO 2222756-24-1](/uploads/202543157/6-bromo-4-6-fluoro-3-pyridinyl-pyrazolo-1-5-ac8df0152-1311-4f3c-839b-8b70ca4cfcd3.png "6-Bromo-4-(6-fluoro-3-pyridinyl)-pyrazolo[1,5-a]pyridine-3-carbonitrile CAS NO 2222756-24-1")
Technical Specification
| Product Name | 6-Bromo-4-(6-fluoro-3-pyridinyl)-pyrazolo[1,5-a]pyridine-3-carbonitrile |
| CAS NO | 2222756-24-1 |
|
MF |
C13H6BrFN4 |
| MW | 317.12 |
| Test items | Standards |
|
Appearance |
White solid |
|
'H NMR Spectrum |
Conforms to structure |
|
ESI-MS |
Conforms to structure |
|
Purity(HPLC) |
99.7% |
|
Loss on drying |
0.2% |
Pyrazolo[1,5-a]pyridine Core Scaffold in Drug Discovery
6-Bromo-4-(6-fluoro-3-pyridinyl)pyrazolo[1,5-a]pyridine is a highly functionalized synthetic intermediate featuring a central pyrazolo[1,5-a]pyridine bicyclic core. As a privileged structure in modern medicinal chemistry, the pyrazolo[1,5-a]pyridine ring system is widely incorporated into bioactive target molecules, particularly in the design of novel kinase inhibitors, receptor modulators, and neuroprotective agents.
Equipped with dual functional handles-a reactive 6-bromo group on the pyrazolo core and a fluorinated pyridine fragment at the C-4 position-this building block offers excellent synthetic versatility for sequential transition-metal-catalyzed cross-couplings (such as Suzuki-Miyaura, Buchwald-Hartwig, and Sonogashira reactions) and late-stage diversification.
Synthetic Applications & Key Features
Cross-Coupling Handle: The aromatic bromide substituent enables efficient carbon-carbon (C-C) and carbon-heteroatom (C-N, C-O) bond-forming reactions to construct complex lead molecules.
Fluorinated Pyridine Ring: The 6-fluoro-3-pyridinyl moiety enhances metabolic stability while offering potential sites for nucleophilic aromatic substitution (SNAr).
SAR Exploration: An ideal intermediate for structure-activity relationship (SAR) studies in medicinal chemistry programs targeting kinases, oncology targets, and central nervous system (CNS) pathways.
Quality Control & Bulk Supply
Joy Biotech is a trusted partner for biotech companies, pharmaceutical enterprises, and research institutes worldwide. We ensure high-quality standards and reliable delivery for all organic synthesis building blocks:
Rigorous Analytical QC: Verified by HPLC, 1H-NMR, and LC-MS. Full batch analytical documentation (COA, MSDS) provided upon request.
Flexible Packaging Scales: Supplied from milligram (mg) research samples to multi-kilogram (kg) pilot-scale production.
Global Logistics: Safe, fast worldwide shipping with reliable chemical compliance handling.
Similar Pyrazolo[1,5-a]pyridine Building Blocks
Explore related structural analogs from our heterocyclic library for parallel synthesis and library screening:
Pyrazolo[1,5-a]pyridine Core Derivatives
6-Bromo-4-chloro-pyrazolo[1,5-a]pyridine
4-(6-Fluoro-3-pyridinyl)pyrazolo[1,5-a]pyridine
Pyrazolo[1,5-a]pyridine-6-boronic acid pinacol ester
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