Product Description
Palmitoyl tripeptide-8 (CAS No 936544-53-5),obtained by way of the response of palmitic acid and tripeptide-8, helps to calm and soothe infection in aggravated skin.
Palmitoyl Tripeptide-8 is a highly efficient, lipophilic 3-amino acid neuropeptide linked to palmitic acid for superior skin penetration. As a pioneering ingredient in neuro-cosmetics, it works at the cellular level to
prevent and soothe neurogenic inflammation. Designed specifically as a premium peptide for sensitive skin, it helps cosmetic formulators create high-performance solutions that actively reduce skin redness, calm hyper-
reactive skin, and restore the skin's biological comfort threshold.
Basic information
- Product Name：Palmitoyl Tripeptide-8
- INCI Name：Palmitoyl Tripeptide-8
- CAS NO.：936544-53-5
- MF： C37H61N9O4
- MW： 695.94
- Function: Moisturizing and Soothing
Application
Reduces irritation and redness
Palmitoyl tripeptide-8 (CAS No 936544-53-5) can reduce irritation caused by UV rays and immune reactions. It can also help calm inflammation, and soothe sensitive skin.Palmitoyl tripeptide-8 can help reduce redness, which is beneficial for people with sensitive skin.
Improves skin elasticity
Palmitoyl tripeptide-8 (CAS No 936544-53-5) can help increase collagen synthesis, which can improve skin elasticity.
Scientific Mechanism: The Neuro-Cosmetics Principle
How It Works: Advanced Neuro-Regulation
Skin sensitivity is often driven by neurogenic pathways where environmental stress triggers the release of neuromediators, causing redness, itching, and swelling. Palmitoyl Tripeptide-8 acts as a specific melanocortin 1 receptor (MC1R) agonist.
By mimicking the body's natural anti-inflammatory peptide (α-MSH), it effectively blocks the cascade of neurogenic inflammation, reduces vasodilation, and prevents cellular damage. It shifts the formulation focus from superficial soothing to deep, neurological skin comfort.
In Vitro Efficacy: Inhibition of Inflammatory Cytokines (IL-8 & TNF-α)
Our lab data demonstrates that Palmitoyl Tripeptide-8 significantly dampens the inflammatory response in human keratinocytes stressed by UV radiation or chemical irritants.
Formulation Stability & Compatibility Report
To ensure seamless integration into sensitive skin products, JoyBio's R&D team performed extensive stability stress tests:
pH Stability Range: Extremely stable between pH 4.0 and 7.5. Perfect for low-pH barrier repair creams and neutral serums.
Thermal Stability: Can withstand manufacturing temperatures up to 80°C for short durations; however, adding it during the cooling phase (<40°C) is recommended for optimal potency.
Compatibility: Non-ionic nature allows complete synergy with hyaluronic acid, ceramides, centella asiatica extracts, and other hypoallergenic cosmetic bases without causing separation or discoloration.
Formulation recommendations
Recommended dosage of Palmitoyl tripeptide-8 in cosmetics
1-5%
Compatibility suggestion
Palmitoyl tripeptide-8 is soluble in water. It has a good compatibility. Avoid compatibility with strong acids, strong alkalis, strong oxidants, acid chloride and anhydride.
Precautions
Palmitoyl tripeptide-8 is bioactive.It's recommended that the operating temperature of the preparation process of Palmitoyl tripeptide-8 be lower than 40 °C, control the PH between 5-7
Packing and delivery
Packing
Two layers of LDPE bags, one layer of Foil pouches, packed in carton or drum according to the quantity of your demand.
Packing can be customized. Regular package is 500g/bag or bottle, 1kg/carton, 10kg/carton, 25kg/drum
Delivery
Shipment term can be by air, by sea, or by express.
Sample can be delivered by DHL, Fedex,UPS,TNT,etc.
Company Profile
Shanghai Joy Biotech Ltd. is a professional supplier of Cosmetic ingredients like Ectoine, pharmaceutical raw materials, Dietary supplements, etc. Our team consists of doctors, masters, Bachelors in the field of pharmaceuticals,chemistry, Biology.
We provide professional service in both export & Import chemical products, and CMO/CDMO .
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