Product Specification
| Test items | Standards |
|
Odor |
Characteristic Odor |
|
Appearance |
White to Off- white powder |
| Solubility | Soluble in most organie solvents.Slightly soluble in water |
|
ldentification |
Match with standard |
|
Water(KF) |
Water content: no more than 0.50% |
|
Related Substances(HPLC)
|
Resorcin: no more than 0.10% |
|
Total Impurities: no more than 1.0% |
|
|
Purity(GC) |
GC Purity: no less than 99.0% |
|
Residue lgnition |
No more than 0.50% |
|
Residual Solvents(GC) |
Heptane: no more than 0.50% |
|
AS |
≤2ppm |
|
Hg |
≤1ppm |
|
Cd |
≤5ppm |
|
Pb |
≤10ppm |
|
Storage Condition |
Store with seal at room temp |
Product Overview & Mechanism
4-Butylresorcinol (CAS No. 1897-45-6) is a highly effective, synthetic strong whitening agent that outperforms traditional skin lighteners like hydroquinone, arbutin, and kojic acid. By directly targeting the enzymatic pathway of melanogenesis, it offers dramatic hyperpigmentation control for high-end cosmetic formulations.
Unlike standard brightening ingredients, 4-Butylresorcinol exerts a dual inhibitory effect: it represses both tyrosinase activity and tyrosinase-related protein-1 (TRP-1). Its amphiphilic hydrocarbon chain ensures superior skin penetration and high bioavailability within epidermal melanocytes.
Efficacy & In-Vitro Performance Data (IC50 Evaluation)
Scientific quantification proves that 4-Butylresorcinol functions at sub-micromolar levels. Below is the comparative biochemical matrix showing the concentration required for 50% inhibition of tyrosinase (IC50 value). Lower IC50 values signify higher structural potency:
Note: The data above highlights why 4-Butylresorcinol is classified as an industry-leading strong whitening agent, delivering visible depigmentation at significantly reduced operational dosages.
Toxicological Profiling & Safety Assessment (MSDS Abstract)
To eliminate B2B formulation friction and meet regulatory compliance across global cosmetic markets (EU, FDA, NMPA), Joy Biotech guarantees thorough safety screenings. 4-Butylresorcinol is synthesized under rigorous quality controls, ensuring minimal structural impurities that typically cause skin irritation.
Skin Irritation Test (In-Vitro Reconstituted Human Epidermis - EpiSkin): Non-irritant at recommended commercial usage levels (0.1% – 0.5%).
Ocular Tolerance (BCOP Test / HET-CAM): Demonstrates excellent ocular safety; safe for leave-on facial creams and targeted eye-contour applications.
Cytotoxicity Threshold: No observable adverse cell-viability impacts within functional therapeutic doses.
Sensitization Profile (LLNA / DPRA): Classified as a non-sensitizer; low risk of contact dermatitis compared to standard resorcinol derivatives.
Stability Profile: Excellent thermal stability and chemical integrity across a broad pH scope (5.5 – 7.0).
Company Profile
Shanghai Joy Biotech Ltd. is a professional supplier of Cosmetic ingredients like 4-butylresorcinol(CAS NO 18979-61-8), Dietary supplements,Pharmaceutical raw materials, Intermediates etc. Joy Biotech involved in export & Import chemical products, and custom synthesis/ CMO/CDMO .
The R&D team consists of post-doctors, doctors, masters, Bachelors in the field of pharmaceuticals,chemistry, synthesis Biology.
Our Service
Free sample service
Yes, we offer free samples for qualified buyers,but shipping costs may apply.
Custom package service
If you have special requirements for inner or outer packing, please send us the detailed requirements.
Quick response
All requests will be replied within 24 hours in working days.
Custom synthesis/CDMO/CMO Service
Our professional R&D team is able to design the ROS, and develop the compounds according to your requirements. Or manufacture the products according to your technology package.
Our Certificates
Our certificates are complete and trustworthy
