Basic
information
Sublancin (CAS 207410-26-2) is a highly specialized, structurally unique glycosylated antimicrobial peptide (specifically a lantibiotic) naturally produced by Bacillus subtilis 168. Unlike standard linear peptides or basic botanical extracts, Sublancin features an innovative dual-thioether bridge configuration coupled with a specific S-linked glucose moiety. This advanced biochemical architecture grants it exceptional bactericidal efficacy, prolonged bioavailability, and superior resistance against proteolytic degradation-making it an elite candidate for pharmaceutical R&D, clinical therapeutics, and premium livestock/dietary supplement formulations.
High-Resolution Antimicrobial Spectrum & MIC Data
Sublancin exerts highly selective and potent bactericidal action primarily targeting Gram-positive pathogens, including multi-drug resistant (MDR) strains, while leaving beneficial microflora relatively uncompromised. Below are the verified Minimum Inhibitory Concentration (MIC) benchmarks evaluated across critical indicator strains:
|
Target Pathogen / Indicator Strain |
Strain Collection ID | MIC Value (μg/ mL) | Clinical Significance / Target Application |
|---|---|---|---|
|
Staphylococcus aureus (MRSA) |
ATCC 43300 | 1.5 – 3.0 | Anti-MDR skin infection & wound-healing research |
|
Clostridium perfringens |
ATCC 13124 | 0.75 – 1.5 | Necrotic enteritis prevention & gut-barrier fortification |
|
Listeria monocytogenes |
ATCC 19115 | 2.0 – 4.0 | Advanced biopreservation & food-safety control |
| Bacillus cereus | ATCC 14579 | 1.0 – 2.0 | Spore-forming pathogen inhibition |
| Streptococcus pneumoniae | ATCC 6303 | 3.0 – 6.0 | Respiratory tract pathogen research |
Dynamic Thermal & pH Stability Profile
A key technical barrier of therapeutic peptides is their tendency to denature under extreme processing conditions. Sublancin overcomes this limitation. Due to its rigid, glucose-interlocked lantibiotic rings, it displays extraordinary thermo-tolerance and structural resilience across wide physical gradients.
Thermal Endurance: Retains >92% biological activity after exposure to 100°C for 60 minutes. Fully compatible with high-temperature pelleting, pasteurization, and extrusion manufacturing processes.
pH Versatility: Remains active and chemically stable across a pH range of 2.0 to 9.0, ensuring survival through gastric transit (low pH) and optimal delivery in intestinal environments.
Protease Resistance: The unique S-glycosylation protects the peptide core from rapid digestion by trypsin and pepsin, extending its in vivo half-life.
Bio-Fermentation Process & Quality Management
Genetic Engineering & Strain Optimization: Hyper-producing strains of Bacillus subtilis are cultivated in optimized bioreactors, ensuring stable expression of the sunA precursor gene and associated processing enzymes (SunT, SunA, SunS).
Fed-Batch Bio-Fermentation: Real-time automated monitoring of dissolved oxygen (DO), carbon source feed-rates, and pH to maximize peptide yield per liter.
Downstream Purification: Utilizing advanced ultrafiltration followed by preparative High-Performance Liquid Chromatography (Prep-HPLC) to eliminate host cell proteins (HCP) and endotoxins.
Lyophilization: Vacuum freeze-drying into a stable crystalline powder, guaranteeing a shelf-life of >24 months when stored under recommended conditions.
Mode of Action (Antimicrobial Mechanism)
Sublancin operates via a sophisticated dual-action mechanism that reduces the risk of pathogens developing bacterial resistance:
Membrane Permeabilization: The amphipathic peptide structure electrostatically binds to the lipid bilayers of target bacterial cells, creating stable transmembrane pores that trigger rapid leakage of essential intracellular ions ( K +, Mg 2+) and ATP, causing cell death.
Cell Wall Synthesis Disruption: Recent research indicates Sublancin interacts with critical cell wall precursors, halting active peptidoglycan assembly.
Our Advantages
Stable Supply Chain:
Key products are backed by strategic safety stock, enabling immediate shipment upon order confirmation.
Our Services
We not only provide qualified products, but also the best pre-sales and after-sales services. Our goal is to build a long-term relationship with every customer.
Competitive Pricing:
We leverage continuous process optimization (increased yield, reduced solvent/waste, efficient sourcing) to offer cost-competitive pricing. Volume discounts available.
FAQ
Q：How do you ensure ingredient quality and traceability?
A：Raw materials are sourced from reliable supplier, and every step and batch undergoes testing.
Q：What documents do you provide with shipments?
A：We supply COA (Certificate of Analysis), MSDS, customs clearance documents, and other documents required by clients.
Q：What shipping methods do you use?
A：We partner with DHL, FedEx, sea and airplane freight providers. Shipping terms (FOB, CIF.CNF...) are negotiable.
Delivery
Accelerated Order Fulfillment
Shipment processing begins immediately upon order confirmation and payment clearance.
Flexible Logistics Solutions
High-Volume: Air & Sea Freight
Small-Scale: Express Courier (DHL/FedEx/UPS)
Operational Efficiency
Strategic Safety Stock Management
Global Logistics Partnerships (DHL/TNT/FedEx)
INCOTERMS Expertise: FOB, CIF, CFR
Nice Package
Packaging size can range from 1 gram to 1 kilogram per bottle or bag, and we offer customized sizes based on your requirements and chemical properties of the product.
We prioritize nice packaging to ensure products are well-protected and arrive in perfect condition.
Company Profile
Shanghai Joy Biotech Ltd. is a professional supplier of dietary supplements, pharmaceutical raw materials, cosmetic ingredients, and related products. Our team comprises doctors, master's degree holders, and bachelor's degree holders specializing in pharmaceuticals, chemistry, and biology.
We provide professional services in export and import of chemical products, as well as CMO/CDMO (Contract Manufacturing Organization/Contract Development and Manufacturing Organization) solutions.
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