Tert-butyl 1-oxo-1,3-dihydrospiro[indene-2,4'-piperidine]-1'-carboxylate CAS NO 1228079-29-5

The 1-oxospiro[indene-2,4'-piperidine] core represents a privileged, rigid 3D framework engineered to elevate the fraction of sp³-hybridized carbons (Fsp³) in lead candidates.

Rigid Spatial Geometry: The orthogonal spiro junction enforces a defined exit-vector profile, projecting functional groups into unique binding sub-pockets while reducing conformational entropy upon target binding.

Dual-Handle Synthetic Versatility:

$N$-Boc Protecting Group: Allows orthogonal deprotection under standard acidic conditions (e.g., TFA/DCM or $\text{HCl}/\text{dioxane}$) to access free secondary amine scaffolds for functionalization, alkylation, or amidation.

Indanone Carbonyl (C=O): Acts as a reactive synthetic handle for reductive amination, nucleophilic addition, stereoselective reduction, or condensation reactions to build diverse lead-like series.

Thermal & Chemical Stability: Thermally stable under standard ambient conditions. Retains structural integrity in non-acidic organic solvents. The -Boc group remains resilient under basic, neutral, and mild catalytic hydrogenation conditions.

Storage Recommendation: Store at 2°C – 8°C (Refrigerated) in a tightly sealed container, protected from direct moisture and strong light. Keep under an inert gas blanket (Nitrogen/Argon) for prolonged bulk storage.

Safety & Handling: Non-hazardous intermediate when handled in accordance with standard industrial good laboratory practices (GLP). (SDS provided upon download).

This novel spirocyclic scaffold is widely utilized as a key building block across exploratory medicinal chemistry pipelines:

CNS & Neuroactive Targets: Used in the design of rigid GPCR modulators (including dopamine, serotonin, and opioid receptor ligands) where conformational restriction improves selectivity and blood-brain barrier (BBB) penetration.

Targeted Oncology & Kinase / Epigenetic Inhibitors: Serves as a conformationally restrained core or linker moiety in allosteric small-molecule inhibitors and PROTAC degrader architectures.

Fragment-Based Drug Discovery (FBDD): Ideal for expanding 3D chemical diversity libraries to escape flat aromatic space and improve solubility and metabolic stability (CYP450profiles).

Shanghai Joy Biotech Ltd. is a professional supplier of cosmetic ingredients (such as Ectoine), pharmaceutical raw materials, dietary supplements, and related products. Our team comprises doctors, master's degree holders, and bachelor's degree holders specializing in pharmaceuticals, chemistry, and biology.

We provide professional services in export and import of chemical products, as well as CMO/CDMO (Contract Manufacturing Organization/Contract Development and Manufacturing Organization) solutions.

Total site Area: 100,000 m² (including Chemical Base: 50,000 m²)
Annual Intermediate Production Capacity: 2,200 MT